{"product_id":"morphogen-nutrition-prime-total-health","title":"Morphogen Nutrition PRIME: Total Health — Full-Spectrum Organ Support | 180 Caps","description":"\u003ch2\u003eMorphogen Nutrition PRIME: Total Health — One Bottle, Every System\u003c\/h2\u003e\n\u003cp\u003eMost \"health\" supplements are a multivitamin with a marketing budget. \u003cstrong\u003eMorphogen Nutrition PRIME: Total Health\u003c\/strong\u003e is not that. It's a 14-ingredient, six-capsule organ support formula built around clinical dosing — the kind of panel that normally takes four separate bottles to assemble. Cardiovascular function, lipid and glucose metabolism, liver protection, mitochondrial output, and systemic oxidative defense, all in a single daily serving.\u003c\/p\u003e\n\u003cp\u003eThis is the reformulated v2 panel. Morphogen kept the backbone that made the original a staple — NAC, arjuna, citrus bergamot, curcumin, milk thistle, grape seed, CoQ10, AstraGin — and layered in alpha lipoic acid, berberine HCl, OLEANO 35® oleanolic acid, PQQ, and MitoPrime®. The result is a formula that doesn't just supply antioxidants; it targets the specific pathways where metabolic and cardiovascular decline actually begins.\u003c\/p\u003e\n\u003ch2\u003eWhy Serious Lifters Run an Organ Support Protocol\u003c\/h2\u003e\n\u003cp\u003eIf you train hard, eat big, and have been doing it for years, your bloodwork is carrying a load your training partner's isn't. High training volume raises systemic oxidative stress. Aggressive caloric intake — especially in a surplus — stresses lipid handling and glucose disposal. Add years of accumulated wear on liver and kidney filtration, and \"I feel fine\" stops being a useful metric. PRIME is built for the athlete who wants their next lab panel to reflect the same discipline as their training log.\u003c\/p\u003e\n\u003ch2\u003eWhat's Inside — And What Each Ingredient Actually Does\u003c\/h2\u003e\n\u003ch3\u003eCardiovascular \u0026amp; Endothelial Support\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCitrus Bergamot (500 mg, 5:1 extract)\u003c\/strong\u003e — Bergamot polyphenols influence HMG-CoA reductase activity and AMPK signaling, the same upstream nodes involved in how the body manages cholesterol synthesis and triglyceride handling. It's one of the few botanicals with human trial data on lipid parameters.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eArjuna (500 mg, 20% polyphenols)\u003c\/strong\u003e — A cardiotonic Ayurvedic bark extract studied for its effect on left ventricular function and vascular tone. Arjuna's polyphenol fraction supports the contractile efficiency of cardiac tissue rather than simply acting as a peripheral vasodilator.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGrape Seed Extract (200 mg, 95% proanthocyanidins)\u003c\/strong\u003e — Proanthocyanidins support microvascular integrity and nitric oxide bioavailability by protecting endothelial nitric oxide synthase from oxidative degradation. Healthy capillaries are the difference between blood pressure that behaves and blood pressure that doesn't.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoenzyme Q10 (50 mg)\u003c\/strong\u003e — Cardiac tissue has the highest mitochondrial density in the body and the highest CoQ10 demand. CoQ10 sits in the electron transport chain at complexes I–III, and myocardial concentrations decline measurably with age.\u003c\/p\u003e\n\u003ch3\u003eMetabolic \u0026amp; Glucose Support\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eBerberine HCl (500 mg)\u003c\/strong\u003e — Berberine activates AMP-activated protein kinase (AMPK), the cell's master energy sensor. AMPK activation increases GLUT4 translocation to the cell membrane, which is the mechanism by which muscle tissue pulls glucose out of the bloodstream. Berberine also modulates gut microbiota composition, a secondary pathway for its effects on lipid and glucose handling.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlpha Lipoic Acid (600 mg)\u003c\/strong\u003e — ALA is unusual in being both water- and fat-soluble, which lets it operate in the cytosol and the membrane. It supports insulin receptor signaling and glucose oxidation while regenerating spent vitamin C, vitamin E, and glutathione back to their active forms.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOLEANO 35® Oleanolic Acid (250 mg, std. 35%, from olive fruit)\u003c\/strong\u003e — A triterpenoid studied for hepatic and renal support and for its modulation of inflammatory signaling. It's a genuinely uncommon inclusion at this dose — most formulas skip it on cost.\u003c\/p\u003e\n\u003ch3\u003eLiver \u0026amp; Detoxification Pathways\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl L-Cysteine (600 mg)\u003c\/strong\u003e — NAC is the rate-limiting precursor for glutathione synthesis. Glutathione is the body's primary endogenous antioxidant and a required cofactor for Phase II liver detoxification. You cannot supplement glutathione orally with much success; you supply the substrate and let the liver build it.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMilk Thistle (250 mg, min. 80% silymarin)\u003c\/strong\u003e — Silymarin stabilizes hepatocyte membranes and supports the liver's regenerative capacity. Standardized to 80% — the ratio that actually shows up in the research, not the 30% filler-grade extract common in cheap formulas.\u003c\/p\u003e\n\u003ch3\u003eMitochondrial \u0026amp; Cellular Longevity\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003ePQQ (20 mg)\u003c\/strong\u003e — Pyrroloquinoline quinone signals through PGC-1α to stimulate \u003cem\u003emitochondrial biogenesis\u003c\/em\u003e — the creation of new mitochondria, not just protection of existing ones. Twenty milligrams is a real dose; most products run 10 mg or less.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMitoPrime® L-Ergothioneine (5 mg)\u003c\/strong\u003e — Ergothioneine is transported into cells by a dedicated transporter (OCTN1) and concentrates specifically in tissues under high oxidative load — mitochondria, liver, red blood cells. Researchers have called it a \"longevity vitamin\" for exactly this reason.\u003c\/p\u003e\n\u003ch3\u003eInflammatory Modulation\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCurcumin (500 mg, 95% curcuminoids)\u003c\/strong\u003e — Curcumin downregulates NF-κB, the transcription factor that turns on inflammatory cytokine production. The 95% standardization plus BioPerine® pairing addresses curcumin's notoriously poor absorption profile.\u003c\/p\u003e\n\u003ch3\u003eAbsorption Technology\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAstraGin® (50 mg)\u003c\/strong\u003e — Full clinical dose. AstraGin upregulates intestinal nutrient transporter expression, improving uptake of amino acids and polyphenols.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioPerine® (5 mg, 95% piperine)\u003c\/strong\u003e — Inhibits the enzymes that metabolize curcumin, CoQ10, and berberine before they reach circulation. Without it, a meaningful fraction of this panel would never make it past first-pass metabolism.\u003c\/p\u003e\n\u003ch2\u003eSupplement Facts\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size: 6 Capsules  |  Servings Per Container: 30\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount Per Serving\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eAlpha Lipoic Acid (ALA)\u003c\/td\u003e\n\u003ctd\u003e600 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eN-Acetyl L-Cysteine (NAC)\u003c\/td\u003e\n\u003ctd\u003e600 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eArjuna (Terminalia arjuna) extract (bark) (std. min. 20% Polyphenols)\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBerberine HCl (Berberis aristata) (bark)\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCitrus Bergamot (Citrus bergamia) extract (fruit) (5:1)\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCurcumin from Turmeric (Curcuma longa) extract (root) (std. min. 95% Curcuminoids)\u003c\/td\u003e\n\u003ctd\u003e500 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOLEANO 35® Oleanolic Acid (std. min. 35%) from Olives (Olea europaea) (fruit)\u003c\/td\u003e\n\u003ctd\u003e250 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMilk Thistle (Silybum marianum) extract (fruit\/seeds) (min. 80% Silymarin)\u003c\/td\u003e\n\u003ctd\u003e250 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGrape Seed (Vitis vinifera) extract (seed) (std. min. 95% Proanthocyanidins)\u003c\/td\u003e\n\u003ctd\u003e200 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAstraGin® (Panax notoginseng and Astragalus membranaceus root extracts)\u003c\/td\u003e\n\u003ctd\u003e50 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCoenzyme Q10 (Ubiquinone)\u003c\/td\u003e\n\u003ctd\u003e50 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePyrroloquinoline Quinone Disodium Salt (PQQ)\u003c\/td\u003e\n\u003ctd\u003e20 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBioPerine® Black Pepper (Piper nigrum) extract (fruit) (std. min. 95% Piperine)\u003c\/td\u003e\n\u003ctd\u003e5 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMitoPrime® (L-Ergothioneine 98%)\u003c\/td\u003e\n\u003ctd\u003e5 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cem\u003ePanel reflects the current v2 formulation. Verify against your physical bottle before publishing — see notes.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eHow to Take PRIME\u003c\/h2\u003e\n\u003cp\u003eTake 6 capsules daily with food. Splitting the serving — 3 capsules with breakfast, 3 with dinner — is the practical approach for most people, and it keeps berberine and ALA closer to meals, which is where they do their work. Berberine in particular is better tolerated when it isn't taken on an empty stomach.\u003c\/p\u003e\n\u003cp\u003eGive it 8–12 weeks and retest bloodwork. Organ support isn't a supplement category you evaluate by feel.\u003c\/p\u003e\n\u003ch2\u003eWho PRIME Is For\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eLifters and athletes running high training volume and high caloric intake\u003c\/li\u003e\n\u003cli\u003eAnyone over 35 who wants to get ahead of age-related metabolic drift\u003c\/li\u003e\n\u003cli\u003ePeople currently buying berberine, NAC, CoQ10, curcumin, and milk thistle separately — this consolidates all of it\u003c\/li\u003e\n\u003cli\u003eAnyone who tracks bloodwork and wants a formula they can point to on a panel\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhy Buy Morphogen at Coalition Nutrition\u003c\/h2\u003e\n\u003cp\u003eWe've been stocking limited-distribution brands since 2013 because we actually use them. Morphogen doesn't sell through mass retail, and there's a reason: the formulas cost too much to make for a big-box margin structure. We carry the full Morphogen HEALTH line, we know which SKUs stack and which overlap, and if you're in Bucks County you can walk into our Langhorne shop and ask.\u003c\/p\u003e\n\u003ch2\u003eMorphogen PRIME — Frequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eWhat does Morphogen PRIME actually do?\u003c\/h3\u003e\n\u003cp\u003ePRIME is a full-spectrum organ support formula. It combines ingredients that support cardiovascular function (citrus bergamot, arjuna, CoQ10, grape seed), metabolic and glucose handling (berberine, alpha lipoic acid), liver function (NAC, milk thistle, oleanolic acid), and mitochondrial health (PQQ, MitoPrime). It's designed to replace four or five separate single-ingredient bottles.\u003c\/p\u003e\n\u003ch3\u003eHow many capsules per serving?\u003c\/h3\u003e\n\u003cp\u003eSix capsules, once daily, with food. The bottle contains 180 capsules for a 30-day supply. Six capsules sounds like a lot until you look at the panel — the first five ingredients alone account for roughly 2.7 grams.\u003c\/p\u003e\n\u003ch3\u003eWhat changed in the new version of PRIME?\u003c\/h3\u003e\n\u003cp\u003eThe v2 reformulation added alpha lipoic acid (600 mg), berberine HCl (500 mg), OLEANO 35® oleanolic acid (250 mg), PQQ (20 mg), and MitoPrime® ergothioneine (5 mg). The original core — NAC, arjuna, citrus bergamot, curcumin, milk thistle, grape seed, CoQ10, and AstraGin® — carried over unchanged.\u003c\/p\u003e\n\u003ch3\u003eCan I take PRIME with a pre-workout or other Morphogen products?\u003c\/h3\u003e\n\u003cp\u003eYes. PRIME is stimulant-free and stacks cleanly with ALPHAGEN, VOLUGEN, or any pre-workout. Check for overlap if you're already running a separate berberine, NAC, or CoQ10 product — you don't need to double up.\u003c\/p\u003e\n\u003ch3\u003eWhen should I take it — morning or night?\u003c\/h3\u003e\n\u003cp\u003eWith food, either time. Many people split it 3 capsules with breakfast and 3 with dinner to keep berberine and ALA near meals and to make six capsules easier on the stomach.\u003c\/p\u003e\n\u003ch3\u003eHow long before I notice anything?\u003c\/h3\u003e\n\u003cp\u003eOrgan support isn't a category you evaluate by feel. Run it consistently for 8–12 weeks and compare bloodwork. That's the honest answer, and it's why the product exists.\u003c\/p\u003e\n\u003ch3\u003eIs PRIME third-party tested?\u003c\/h3\u003e\n\u003cp\u003eMorphogen products are manufactured in GMP-certified, FDA-registered facilities in the USA, with random third-party testing for quality control.\u003c\/p\u003e\n\u003ch3\u003eShould I take PRIME if I'm on prescription medication?\u003c\/h3\u003e\n\u003cp\u003eTalk to your physician first. Berberine and alpha lipoic acid both influence glucose handling, and citrus bergamot affects lipid metabolism — all of which matter if you're already on medication in those categories. This isn't boilerplate; it's the one genuinely important caveat with this formula.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your physician before use, particularly if you take prescription medication for blood sugar, blood pressure, or cholesterol management.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Morphogen Nutrition","offers":[{"title":"Default Title","offer_id":46482324914255,"sku":null,"price":62.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1009\/8986\/files\/2026-08-24T113814.814.png?v=1787595772","url":"https:\/\/www.coalitionnutrition.com\/products\/morphogen-nutrition-prime-total-health","provider":"Coalition Nutrition","version":"1.0","type":"link"}